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TANGO / MIA3

melanoma inhibitory activity family, member 3

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1.

Gene Name:	melanoma inhibitory activity family, member 3
Synonyms:	MIA3, C219-reactive peptide, D320, KIAA0268, RP11-378J18.4, TANGO, TANGO1, UNQ6077, C219 reactive peptide
Target Sequences:	D87742 BAA13448.1 Q5JRA6

Publications (2)

SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum. Nogueira C, Erlmann P, Villeneuve J, Santos AJ, Martínez-Alonso E, Martínez-Menárguez JÃ, Malhotra V. eLife. 2014 3:e02784. (ELISA; Human) [Full Text Article] [PubMed:24842878] [PMC:PMC4054776] Related Antibodies: LS-C395475.

Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. Miyako Kurihara-Shimomura, Tomonori Sasahira, Hiroyuki Shimomura, Anja Katrin Bosserhoff, Tadaaki Kirita. International journal of oncology. 2020 May;56:1093-1100. [Full Text Article] [PubMed:32319583] Related Antibodies: LS-B4210.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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