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TAGLN / Transgelin / SM22

transgelin

TAGLN / Transgelin / SM22 is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: transgelin
Synonyms: TAGLN, 22 kDa actin-binding protein, SMCC, TAGLN1, WS3-10, Transgelin, Transgelin variant 2, SM22, Protein WS3-10, SM22-alpha
Target Sequences: NM_003186 NP_003177.2 Q01995

Publications (4)

1
Proteomic profiling of chronic low-frequency stimulated fast muscle. Donoghue P, Doran P, Wynne K, Pedersen K, Dunn MJ, Ohlendieck K. Proteomics. 2007 7:3417-30. [PubMed:17708595] Related Antibodies: LS-B2563.
2
Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells. Nincheri P, Luciani P, Squecco R, Donati C, Bernacchioni C, Borgognoni L, Luciani G, Benvenuti S, Francini F, Bruni P. Cellular and molecular life sciences : CMLS. 2009 66:1741-54. [PubMed:19337690] Related Antibodies: LS-B2563.
3
Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis. Cencetti F, Bernacchioni C, Nincheri P, Donati C, Bruni P. Molecular biology of the cell. 2010 21:1111-24. [PubMed:20089836] [PMC:PMC2836962] Related Antibodies: LS-B2563.
4
Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. Donati C, Marseglia G, Magi A, Serrat S, Cencetti F, Bernacchioni C, Nannetti G, Benelli M, Brunelli S, Torricelli F, Cossu G, Bruni P. PloS one. 2011 6:e20389. [PubMed:21629665] [PMC:PMC3101247] Related Antibodies: LS-B2563.
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Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
TAGLN / Transgelin / SM22 (11)
No (11)
GST (2)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (6)
Human (9)
293T Cells (2)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (2)
TAGLN / Transgelin / SM22 Protein - Recombinant Transgelin By SDS-PAGE
Select
E. coli
His, N-Terminal
26.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
E. coli
GST
49.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TAGLN / Transgelin / SM22 Protein
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E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
TAGLN / Transgelin / SM22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
100 µg/$494
TAGLN / Transgelin / SM22 Protein - 12.5% SDS-PAGE of human TAGLN stained with Coomassie Blue
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Wheat Germ Extract
GST
47.85 kDa
10 µg/$479; 25 µg/$670
TAGLN / Transgelin / SM22 Protein - Purified recombinant protein TAGLN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$1,107
TAGLN / Transgelin / SM22 Protein - Purified recombinant protein TAGLN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$1,107
TAGLN / Transgelin / SM22 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$150
TAGLN / Transgelin / SM22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$150
TAGLN / Transgelin / SM22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).