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TADA2L / ADA2A
transcriptional adaptor 2A
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
| Gene Name: | transcriptional adaptor 2A |
| Synonyms: | TADA2A, ADA2A, ADA2-like protein, ADA2, KL04P, HADA2, Transcriptional adapter 2-like, Transcriptional adaptor 2A, TADA2L |
| Target Sequences: | NM_001488 NP_001479.4 O75478 |
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