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TACR3 / NK3R

tachykinin receptor 3

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Gene Name: tachykinin receptor 3
Family/Subfamily: GPCR , Tachykinin
Synonyms: TACR3, HH11, Nmk-r, NK3R, NKR, Tachykinin receptor 3, Neurokinin B, Neurokinin B receptor, NK-3 receptor, NK-3R, TAC3R, Neurokinin 3 receptor, Neurokinin beta receptor, Neuromedin-K receptor, TAC3RL
Target Sequences: NM_001059 NP_001050.1 P29371

Publications (10)

1
Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex. Tooney PA, Au GG, Chahl LA. Neuroscience letters. 2000 283:185-8. (IHC; Human) [PubMed:10754218]
2
Localization of NK1 and NK3 receptors in guinea-pig brain. Yip J, Chahl LA. Regulatory peptides. 2001 98:55-62. [PubMed:11179779]
3
The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Dick O, tom Dieck S, Altrock WD, Ammermller J, Weiler R, Garner CC, Gundelfinger ED, Brandsttter JH. Neuron. 2003 37:775-86. [PubMed:12628168]
4
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. Feigenspan A, Janssen-Bienhold U, Hormuzdi S, Monyer H, Degen J, Shl G, Willecke K, Ammermller J, Weiler R. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 24:3325-34. [PubMed:15056712]
5
Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus. Haley GE, Flynn FW. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 290:R1242-50. [PubMed:16357093]
6
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus. Burke MC, Letts PA, Krajewski SJ, Rance NE. The Journal of comparative neurology. 2006 498:712-26. [PubMed:16917850]
7
Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:1679-84. (ICC; Mouse) [PubMed:17242361] [PMC:PMC1780067]
8
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE. Neuroscience. 2010 166:680-97. (ICC, IHC; Rat) [PubMed:20038444] [PMC:PMC2823949]
9
Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats. Sawai N, Iijima N, Takumi K, Matsumoto K, Ozawa H. Neuroscience research. 2012 74:6-Oct. (ICC, IHC; Rat) [PubMed:22691459]
10
Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Sep;301:R822-31. [Full Text Article] [PubMed:21697521] [PMC:PMC3174760] Related Antibodies: LS-C73388.
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TACR3 / NK3R Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human TACR3 / NK3R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77651
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TACR3 / NK3R Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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TACR3 / NK3R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119355
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