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TAC1

tachykinin, precursor 1

TAC1 / Substance P is four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: tachykinin, precursor 1
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: TAC1, Hs.2563, Neurokinin 1, Neurokinin 2, Neuromedin L, Neuropeptide K, NK2, NPK, Protachykinin beta, Protachykinin-1, Substance K, Substance P, Tachykinin, precursor 1, Neurokinin A, Neuropeptide gamma, PPT, Neurokinin alpha, NKA, NKNA, TAC2, Tachykinin 2
Target Sequences: NM_003182 NP_003173.1 P20366

Publications (3)

1
Characterization of Autonomic Nerve Markers and Lymphocyte Subsets in the Ileal Peyer’s Patch of Pigs Infected Experimentally with Brachyspira hyodysenteriae. J. Kaleczyc, P. Podlasz, A. Winnick, W. Wasowicz, W. Sienkiewicz, J. Zmudzki and M. Lakomy. Journal of comparative pathology. 2010 143:248-57. (IHC-Fr; Pig) [Full Text Article] [PubMed:20605161]
2
Up-regulated expression of substance P in CD8(+) T cells and NK1R on monocytes of atopic dermatitis. Zhang Z, Zheng W, Xie H, Chai R, Wang J, Zhang H, He S. Journal of translational medicine. 2017 15:93. (IHC; Human) [Full Text Article] [PubMed:28460633] [PMC:PMC5412038]
3
Neuropeptides and lymphocyte populations in the porcine ileum and ileocecal lymph nodes during postnatal life. Krzysztof Wasowicz, Anna Winnicka, Jerzy Kaleczyc, Michal Zalecki, Piotr Podlasz, Zenon Pidsudko. PloS one. 2018 May;13:e0196458. [Full Text Article] [PubMed:29813072] [PMC:PMC5973590]

☰ Filters
Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (5)
Synthetic Peptide (1)
TAC1 (8)
No (8)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (6)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Synthetic (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
TAC1  Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
11.38 kDa
100 µg/$494
TAC1  Protein - 12.5% SDS-PAGE of human TAC1 stained with Coomassie Blue
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Wheat Germ Extract
GST
41.4 kDa
2 µg/$439
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Synthetic
None
1347.5 Da
5 mg/$323
TAC1  Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TAC1  Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
11.38 kDa
20 µg/$150
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.2 kDa
10 µg/$344; 50 µg/$584
TAC1  Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Viewing 1-8 of 8 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).