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SYT1 / Synaptotagmin

synaptotagmin I

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.

Gene Name: synaptotagmin I
Family/Subfamily: Synaptotagmin , Not assigned-Other
Synonyms: SYT1, SYT, SVP65, Synaptotagmin, Synaptotagmin 1, SytI, Synaptotagmin I, Synaptotagmin-1
Target Sequences: NM_005639 NP_005630.1 P21579

Publications (2)

1
Eyes shut homolog (EYS) interacts with matriglycan of O-mannosyl glycans whose deficiency results in EYS mislocalization and degeneration of photoreceptors. Yu Liu , Miao Yu , Xuanze Shang, My Hong Hoai Nguyen, Shanmuganathan Balakrishnan, Rachel Sager, Huaiyu Hu. Scientific reports. 2020 May;10:7795. [Full Text Article] [PubMed:32385361] [PMC:PMC7210881] Related Antibodies: LS-B5899.
2
16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis. Danielle L Tomasello, Jiyoon L Kim, Yara Khodour, Jasmine M McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H Futerman, Hazel Sive. iScience. 2022 January;25:103551. [Full Text Article] [PubMed:34984324] [PMC:PMC8693007] Related Antibodies: LS-B12889.

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Products
Proteins (13)
Over-Expression Lysate (6)
Recombinant (7)
SYT1 / Synaptotagmin (13)
No (13)
GST (1)
His (2)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (10)
293T Cells (3)
E. coli (3)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (3)
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
SYT1 / Synaptotagmin Protein - Recombinant Synaptotagmin I By SDS-PAGE
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E. coli
His-T7
36.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Purified recombinant protein SYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$1,107
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.4 kDa
20 µg/$150
Select
E. coli
His
40.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
SYT1 / Synaptotagmin Protein - 12.5% SDS-PAGE of human SYT1 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.16 kDa
10 µg/$479; 25 µg/$670
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
SYT1 / Synaptotagmin Protein
Select
E. coli
His
10 µg/$361; 50 µg/$739
SYT1 / Synaptotagmin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.4 kDa
100 µg/$494
Viewing 1-13 of 13 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).