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Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release.
Gene Name: | synaptophysin |
Synonyms: | SYP, MRX, Synaptophysin, MRXSYP |
Target Sequences: | X06389 CAA29686.1 P08247 |
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