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SYNE4 / C19orf46
spectrin repeat containing, nuclear envelope family member 4
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning By similarity. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.
| Gene Name: | spectrin repeat containing, nuclear envelope family member 4 |
| Synonyms: | SYNE4, C19orf46, Nesprin-4, Nesp4 |
| Target Sequences: | AA991508 Q8N205 Q8N205 |
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