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Syndapin I / PACSIN1

protein kinase C and casein kinase substrate in neurons 1

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission By similarity. Binds to membranes via its F-BAR domain and mediates membrane tubulation.

Gene Name: protein kinase C and casein kinase substrate in neurons 1
Synonyms: PACSIN1, KIAA1379, Syndapin I, SDPI
Target Sequences: AB037800 BAA92617.2 Q9BY11

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
Syndapin I / PACSIN1 (6)
No (6)
6His, C-terminus (2)
GST (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Syndapin I / PACSIN1 Protein - Purified recombinant protein PACSIN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$1,107
Syndapin I / PACSIN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
50.8 kDa
20 µg/$150
Syndapin I / PACSIN1 Protein - 12.5% SDS-PAGE of human PACSIN1 stained with Coomassie Blue
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Wheat Germ Extract
GST
74.58 kDa
10 µg/$479; 25 µg/$670
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.0 kDa
10 µg/$344; 50 µg/$584
Syndapin I / PACSIN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
50.8 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).