SYN / FYN

FYN oncogene related to SRC, FGR, YES

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

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Products

Proteins (14)

Type

Over-Expression Lysate (7)

Recombinant (7)

Target

SYN / FYN (14)

Publications

No (14)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-S (1)

Myc-DDK (Flag) (9)

Species

Human (11)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Purification

Purified (1)

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SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105851

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

100 µg/$494

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Human SYN / FYN Protein (Recombinant GST) (Full Length) - LS-G28536

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SYN / FYN Protein (Over-Expression Lysate 6His, N-terminus) (Gly2-Leu482) - LS-G26775

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

60 kDa

Price:

100 µg/$298

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Human SYN / FYN Protein (Recombinant His-S) (aa2-537) - LS-G26068

Source:

E. coli

Tag:

His-S

Molecular Weight:

64.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human SYN / FYN Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G58623

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SYN / FYN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66756

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

20 µg/$1,107

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Human SYN / FYN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66755

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$1,107

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Human SYN / FYN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66754

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

20 µg/$1,107

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Human SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78438

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

20 µg/$215

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Human SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78440

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$215

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Human SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78441

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.3 kDa

Price:

20 µg/$150

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SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102389

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

100 µg/$710

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SYN / FYN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99629

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

100 µg/$710

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Human SYN / FYN Protein (Recombinant His, N-Terminal) (Gly2-Leu482) - LS-G96906

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

60 kDa

Price:

10 µg/$265; 50 µg/$315

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