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SYCP3 / SCP3

synaptonemal complex protein 3

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2.

Gene Name: synaptonemal complex protein 3
Synonyms: SYCP3, SCP3, SPGF4, Synaptonemal complex protein 3, SCP-3, COR1
Target Sequences: NM_153694 NP_710161.1 Q8IZU3

Publications (18)

1
Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation. Dann CT, Alvarado AL, Molyneux LA, Denard BS, Garbers DL, Porteus MH. Stem cells (Dayton, Ohio). 2008 26:2928-37. [PubMed:18719224]
2
The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. Grimaldi P, Orlando P, Di Siena S, Lolicato F, Petrosino S, Bisogno T, Geremia R, De Petrocellis L, Di Marzo V. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:11131-6. [PubMed:19541620] [PMC:PMC2708706]
3
Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis. Caires KC, de Avila J, McLean DJ. Reproduction (Cambridge, England). 2009 138:667-77. (IHC; Bovine) [PubMed:19633133]
4
Microgravity promotes differentiation and meiotic entry of postnatal mouse male germ cells. Pellegrini M, Di Siena S, Claps G, Di Cesare S, Dolci S, Rossi P, Geremia R, Grimaldi P. PloS one. 2010 5:e9064. [PubMed:20140225] [PMC:PMC2816218]
5
Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. Barrios F, Filipponi D, Pellegrini M, Paronetto MP, Di Siena S, Geremia R, Rossi P, De Felici M, Jannini EA, Dolci S. Journal of cell science. 2010 123:871-80. (WB) [PubMed:20159962]
6
Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, Westwood JT, Christians ES. Molecular and cellular biology. 2011 31:3410-23. [PubMed:21690297] [PMC:PMC3147796]
7
Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro. Medrano JV, Ramathal C, Nguyen HN, Simon C, Reijo Pera RA. Stem cells (Dayton, Ohio). 2012 30:441-51. [PubMed:22162380]
8
Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus). Lin ZY, Imamura M, Sano C, Nakajima R, Suzuki T, Yamadera R, Takehara Y, Okano HJ, Sasaki E, Okano H. Reproduction (Cambridge, England). 2012 143:597-609. (IHC) [PubMed:22323619]
9
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Nature medicine. 2012 18:413-21. [PubMed:22366948] [PMC:PMC3296965]
10
HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. Genes to cells : devoted to molecular & cellular mechanisms. 2012 17:439-54. (ICC, IHC; Mouse) [PubMed:22530760]
11
Invitro production of haploid cells after coculture of CD49f+ with Sertoli cells from testicular sperm extraction in nonobstructive azoospermic patients. Riboldi M, Rubio C, Pellicer A, Gil-Salom M, Simn C. Fertility and sterility. 2012 98:580-590.e4. (ICC; Human) [PubMed:22732736]
12
Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry. Jrgensen A, Nielsen JE, Jensen MB, Grm N, Rajpert-De Meyts E. Molecular human reproduction. 2012 18:523-34. (IHC; Human) [PubMed:22899867]
13
Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1. Greenlee AR, Shiao MS, Snyder E, Buaas FW, Gu T, Stearns TM, Sharma M, Murchison EP, Puente GC, Braun RE. PloS one. 2012 7:e46359. (ICC; Mouse) [PubMed:23056286] [PMC:PMC3464243]
14
Germ cells are not required to establish the female pathway in mouse fetal gonads. Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B. PloS one. 2012 7:e47238. (ICC, IHC-Fr; Mouse) [PubMed:23091613] [PMC:PMC3473035]
15
The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation. Gkountela S, Li Z, Vincent JJ, Zhang KX, Chen A, Pellegrini M, Clark AT. Nature cell biology. 2013 15:113-22. (ICC, IHC; Human) [PubMed:23242216]
16
Deleted in azoospermia-like enhances in vitro derived porcine germ cell formation and meiosis. Park BW, Shen W, Linher-Melville K, Li J. Stem cells and development. 2013 22:939-50. [PubMed:23259838] [PMC:PMC3585486]
17
HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J. Molecular biology of the cell. 2014 25:2260-71. (IHC; Mouse) [Full Text Article] [PubMed:24899640] [PMC:PMC4116300]
18
Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes. Judith Reichmann, Karen Dobie, Lisa M Lister, James H Crichton, Diana Best, Marie MacLennan, David Read, Eleanor S Raymond, Chao-Chun Hung, Shelagh Boyle, Katsuhiko Shirahige, Howard J Cooke, Mary Herbert, Ian R Adams. The Journal of cell biology. 2020 May;219: [Full Text Article] [PubMed:32232464] [PMC:PMC7199850] Related Antibodies: LS-B175.
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SYCP3 / SCP3 (6)
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SYCP3 / SCP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28.2 kDa
100 µg/$494
SYCP3 / SCP3 Protein - 12.5% SDS-PAGE of human SYCP3 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.1 kDa
2 µg/$439
SYCP3 / SCP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
27.5 kDa
100 µg/$494
SYCP3 / SCP3 Protein - Purified recombinant protein SYCP3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
27.5 kDa
20 µg/$1,107
SYCP3 / SCP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
28.2 kDa
20 µg/$150
SYCP3 / SCP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.5 kDa
20 µg/$150
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).