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SWR1 / SRCAP

Snf2-related CREBBP activator protein

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

Gene Name:	Snf2-related CREBBP activator protein
Synonyms:	SRCAP, DOMO1, FLHS, Helicase SRCAP, KIAA0309, Snf2-related CBP activator, SWR1, Domino homolog 2
Target Sequences:	NM_006662 NP_006653.2 Q6ZRS2

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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