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SUV420H2

suppressor of variegation 4-20 homolog 2 (Drosophila)

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

Gene Name:	suppressor of variegation 4-20 homolog 2 (Drosophila)
Synonyms:	SUV420H2, Suv4-20h2, Lysine N-methyltransferase 5C, Su(var)4-20 homolog 2, KMT5C
Target Sequences:	NM_032701 NP_116090.2 Q86Y97

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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