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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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SUPT6H / SPT6

suppressor of Ty 6 homolog (S. cerevisiae)

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Gene Name: suppressor of Ty 6 homolog (S. cerevisiae)
Synonyms: SUPT6H, HSPT6, SPT6, Tat-cotransactivator 2 protein, SPT6H, Emb-5, KIAA0162, Tat-CT2 protein
Target Sequences: AC092209 NP_003161.2 Q7KZ85

Viewing 1-25 of 38 items
SUPT6H / SPT6 Antibody - Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Mouse, Human
IHC, IP, WB
Unconjugated
100µl   0.2mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, IP, WB
Unconjugated
100µg   $355.00
SUPT6H / SPT6 Antibody - Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Mouse, Human
IHC, WB
Unconjugated
100µl   0.2mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
SUPT6H / SPT6 Antibody - Detection of Human SUPT6H by Immunohistochemistry. Sample: FFPE section of human small cell lung cancer. Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:500.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Mouse, Human
IHC
Unconjugated
100µl   $415.00
SUPT6H / SPT6 Antibody - SUPT6H / SPT6 antibody Western Blot of Colorectal Tumor. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
SUPT6H / SPT6 Antibody - SUPT6H / SPT6 antibody Western Blot of Colorectal Tumor. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
SUPT6H / SPT6 Antibody - SUPT6H / SPT6 antibody Western Blot of Colorectal Tumor. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
SUPT6H / SPT6 Antibody - SUPT6H / SPT6 antibody Western Blot of Colorectal Tumor. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100µl   1mg/ml   $385.00
SUPT6H / SPT6 Antibody - Western blot of Human Lung Tumor. SUPT6H antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
SUPT6H / SPT6 Antibody - Western blot of recombinant SUPT6H / SPT6.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $315.00; 1ml   0.5mg/ml   $575.00
SUPT6H / SPT6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $325.00
SUPT6H / SPT6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
WB
HRP Conjugated
100µl   0.65mg/ml   $335.00
SUPT6H / SPT6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
WB
Biotin Conjugated
100µl   1mg/ml   $335.00
SUPT6H / SPT6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey
WB
FITC Conjugated
100µl   1mg/ml   $335.00
SUPT6H / SPT6 Antibody - SUPT6H antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
SUPT6H / SPT6 Antibody - SUPT6H Antibody western blot of 293 cell line lysates (35 ug/lane). The SUPT6H antibody detected the SUPT6H protein (arrow).
Select
Rabbit Polyclonal to Human SUPT6H / SPT6
Human
WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IP
Unconjugated
100µl   1mg/ml   $395.00

Viewing 1-25 of 38 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).