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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SUPT6H / SPT6

suppressor of Ty 6 homolog (S. cerevisiae)

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Gene Name: suppressor of Ty 6 homolog (S. cerevisiae)
Synonyms: SUPT6H, HSPT6, SPT6, Tat-cotransactivator 2 protein, SPT6H, Emb-5, KIAA0162, Tat-CT2 protein
Target Sequences: AC092209 NP_003161.2 Q7KZ85

Filtered By: None
Target
SUPT6H / SPT6 (39)
Reactivity
Human (39)
Mouse (16)
Rat (16)
Bat (12)
Bovine (19)
Chicken (15)
Chimpanzee (9)
Dog (20)
Gibbon (12)
Guinea pig (16)
Hamster (4)
Horse (19)
Monkey (16)
Orangutan (3)
Pig (18)
Rabbit (19)
Xenopus (1)
Zebrafish (1)
Application
IHC (11)
IHC-P (3)
WB (37)
ELISA (8)
ICC (2)
IF (3)
IP (3)
Host
rabbit (39)
Isotype
IgG (26)
Clonality
polyclonal pc (39)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (2)
Unconjugated (12)
Epitope
aa538-666 (10)
N-Terminus (8)
aa99-127 (8)
aa1660-1709 (4)
aa71-120 (4)
aa425-475 (2)
C-Terminus (1)
aa1050-1100 (1)
Publications
No (39)
Showing 1-25 of 39 results

SUPT6H / SPT6 Antibody (aa425-475) LS-C287658
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human
IF IHC IHC-P IP WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

SUPT6H / SPT6 Antibody (aa1050-1100) LS-C287660
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Xenopus, Zebrafish, Rat, Mouse, Dog, Human
IF IHC IHC-P WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
Detection of Human and Mouse SUPT6H by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

SUPT6H / SPT6 Antibody (aa425-475) LS-C286459
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human SUPT6H by Immunohistochemistry. Sample: FFPE section of human small cell lung cancer. Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:500.
Detection of Mouse SUPT6H by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:500.
Detection of Human SUPT6H by Immunohistochemistry. Sample: FFPE section of human small cell lung cancer. Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:500.
Detection of Mouse SUPT6H by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SUPT6H used at a dilution of 1:500.

SUPT6H / SPT6 Antibody LS-C753100
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA IP WB
Unconjugated
100µg  $355.00

SUPT6H / SPT6 Antibody (aa538-666) LS-C315034
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,295.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, HRP) LS-C714605
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $295.00; 200µl  $355.00; 1ml  $740.00; 10ml  $2,985.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, Biotin) LS-C689491
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
Biotin Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, Biotin) LS-C425075
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $395.00

SUPT6H / SPT6 Antibody (aa538-666, FITC) LS-C425076
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $415.00

SUPT6H / SPT6 Antibody (aa538-666, FITC) LS-C696611
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,760.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, Cy3) LS-C705589
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
Cy3 Conjugated
20µl  $255.00; 100µl  $375.00; 200µl  $465.00; 1ml  $1,140.00; 10ml  $4,605.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, APC) LS-C719712
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $325.00; 200µl  $395.00; 1ml  $860.00; 10ml  $7,170.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, PE) LS-C728674
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,760.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa538-666, APC, Cy7) LS-C737536
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
IHC WB
APC, Cy7 Conjugated
20µl  $295.00; 100µl  $485.00; 200µl  $695.00; 1ml  $1,725.00; 10ml  $6,900.00
Western blot of recombinant SUPT6H / SPT6.
Western blot of recombinant SUPT6H / SPT6.

SUPT6H / SPT6 Antibody (aa99-127) LS-C325503
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
Unconjugated
200µl  $530.00

SUPT6H / SPT6 Antibody (aa99-127, Biotin) LS-C270741
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

SUPT6H / SPT6 Antibody (aa99-127, FITC) LS-C270742
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
FITC Conjugated
200µl  $680.00

SUPT6H / SPT6 Antibody (aa99-127, AP) LS-C270739
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
AP Conjugated
200µl  $680.00

SUPT6H / SPT6 Antibody (aa99-127, APC) LS-C270740
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
APC Conjugated
200µl  $680.00

SUPT6H / SPT6 Antibody (aa99-127, Azide-free, HRP) LS-C270743
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

SUPT6H / SPT6 Antibody (aa99-127, PE) LS-C270744
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Human
ELISA WB
PE Conjugated
200µl  $680.00

SUPT6H / SPT6 Antibody (aa71-120) LS-C109784
Rabbit Polyclonal to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
SUPT6H antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
SUPT6H antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUPT6H / SPT6 Antibody (N-Terminus) LS-C201276
Rabbit Polyclonal to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
Western blot of Human Lung Tumor. SUPT6H antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human Lung Tumor. SUPT6H antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUPT6H / SPT6 Antibody (aa99-127) LS-C161621
Rabbit Polyclonal to Human SUPT6H / SPT6
Human
WB
Unconjugated
400µl  $305.00
SUPT6H Antibody western blot of 293 cell line lysates (35 ug/lane). The SUPT6H antibody detected the SUPT6H protein (arrow).
SUPT6H Antibody western blot of 293 cell line lysates (35 ug/lane). The SUPT6H antibody detected the SUPT6H protein (arrow).

SUPT6H / SPT6 Antibody (N-Terminus) LS-C31490
Rabbit Polyclonal (IgG) to Human SUPT6H / SPT6
Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Human, Monkey
WB
Unconjugated
100µg  $325.00
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 39 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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