SUPT4H1 / SPT4

suppressor of Ty 4 homolog 1 (S. cerevisiae)

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

SUPT4H1 / SPT4 (7)

Publications

No (7)

Tag

GST (2)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (3)

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SUPT4H1 / SPT4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117512

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13 kDa

Price:

100 µg/$494

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Human SUPT4H1 / SPT4 Protein (Recombinant GST) (Full Length) - LS-G30595

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

39.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SUPT4H1 / SPT4 Protein (Recombinant GST) (Full Length) - LS-G30592

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.61 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SUPT4H1 / SPT4 Protein (Recombinant GST, N-terminus) (aa1-117) - LS-G64223

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human SUPT4H1 / SPT4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68149

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13 kDa

Price:

20 µg/$1,107

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Human SUPT4H1 / SPT4 Protein (Recombinant GST, N-terminus) (aa18-117) - LS-G60253

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SUPT4H1 / SPT4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81549

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13 kDa

Price:

20 µg/$150

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