SUPT4H1 / SPT4

suppressor of Ty 4 homolog 1 (S. cerevisiae)

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

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Products

Antibodies (17)

Type

Primary (17)

Target

SUPT4H1 / SPT4 (17)

Reactivity

Human (16)

Mouse (7)

Rat (7)

Bovine (4)

Chimpanzee (3)

Guinea pig (3)

Horse (3)

Monkey (1)

Pig (3)

Rabbit (3)

Application

IHC (4)

IHC-P (2)

WB (15)

DB (1)

ELISA (4)

IF (1)

Peptide-ELISA (1)

Host

rabbit (11)

mouse (6)

Isotype

IgG (4)

IgG1 (4)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (6)

polyclonal pc (11)

Clone

3079C1a (1)

3G4 (1)

OTI5F12 (2)

OTI6B10 (2)

Format

Biotin Conjugated (1)

Carrier-free (2)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (14)

Epitope

aa57-106 (4)

C-Terminus (1)

Publications

No (17)

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SUPT4H1 / SPT4 Antibody (clone 3G4) LS-C198288

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (3G4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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SUPT4H1 / SPT4 Antibody LS-C676563

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SUPT4H1 / SPT4 Antibody LS-C676564

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SUPT4H1 / SPT4 Antibody LS-C807395

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SUPT4H1 / SPT4 Antibody LS-C409480

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SUPT4H1 / SPT4 Antibody LS-C778742

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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SUPT4H1 / SPT4 Antibody (clone 3079C1a) LS-C342517

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (3079C1a) Antibody

Reactivity:

Human

Applications:

DB, WB

Format:

Unconjugated

Price:

100 µg/$486

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SUPT4H1 / SPT4 Antibody (clone OTI5F12) LS-C338742

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (OTI5F12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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SUPT4H1 / SPT4 Antibody (clone OTI5F12, Carrier-free) LS-C799534

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (Carrier-free) (OTI5F12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SUPT4H1 / SPT4 Antibody (clone OTI6B10) LS-C340630

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (OTI6B10) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SUPT4H1 / SPT4 Antibody (clone OTI6B10, Carrier-free) LS-C799535

Antibody:

SUPT4H1 / SPT4 Mouse anti-Human Monoclonal (Carrier-free) (OTI6B10) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SUPT4H1 / SPT4 Antibody LS-C411678

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

SUPT4H1 / SPT4 Antibody (C-Terminus) LS-C358345

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

SUPT4H1 / SPT4 Antibody (aa57-106) LS-C170126

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Rat Polyclonal (aa57-106) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUPT4H1 / SPT4 Antibody (aa57-106, HRP) LS-C432947

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Rat Polyclonal (aa57-106) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SUPT4H1 / SPT4 Antibody (aa57-106, Biotin) LS-C432946

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Rat Polyclonal (aa57-106) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SUPT4H1 / SPT4 Antibody (aa57-106, FITC) LS-C432948

Antibody:

SUPT4H1 / SPT4 Rabbit anti-Rat Polyclonal (aa57-106) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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