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SUN1

Sad1 and UNC84 domain containing 1

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope.

Gene Name:	Sad1 and UNC84 domain containing 1
Synonyms:	SUN1, KIAA0810, Protein unc-84 homolog A, UNC84A, Sad1/unc-84 protein-like 1, Unc-84 homolog A, Unc-84 homolog A (C. elegans), Sad1 unc-84 domain protein 1
Target Sequences:	AF202724 AAF15888.1 O94901

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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