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SUMO2

small ubiquitin-like modifier 2

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Gene Name: small ubiquitin-like modifier 2
Synonyms: SUMO2, HSMT3, SMT3 homolog 2, SMT3A, Sentrin 2, Smt3B, SMT3H2, SUMO-2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Ubiquitin-like protein SMT3B
Target Sequences: NM_006937 NP_008868.3 P61956

Publications (2)

1
SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. The Journal of biological chemistry. 2005 280:24330-8. [PubMed:15857832]
2
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A. Human molecular genetics. 2010 19:181-95. [PubMed:19843541] Related Antibodies: LS-C98825.

☰ Filters
Products
Proteins (15)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (9)
SUMO2 (15)
No (15)
6His, N-terminus (4)
8His, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (1)
His-GST (1)
Myc-DDK (Flag) (6)
Human (13)
293T Cells (2)
E. coli (5)
HEK 293 Cells (7)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
SUMO2 Protein
Select
HEK 293 Cells
His, N-Terminal
11 kDa-18 kDa
10 µg/$289; 50 µg/$360
SUMO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
7.9 kDa
100 µg/$494
SUMO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
10.7 kDa
100 µg/$494
SUMO2 Protein - 12.5% SDS-PAGE of human SUMO2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
36.19 kDa
10 µg/$479; 25 µg/$670
Select
HEK 293 Cells
6His, N-terminus
13.2 kDa
200 µl/$283
SUMO2 Protein - Recombinant  Small Ubiquitin Related Modifier Protein 2 By SDS-PAGE
Select
E. coli
His-GST
40.9 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
Select
HEK 293 Cells
8His, N-terminus
13.2 kDa
100 µg/$298
SUMO2 Protein - Purified recombinant protein SUMO2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
10.7 kDa
20 µg/$1,107
SUMO2 Protein - Purified recombinant protein SUMO2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
7.9 kDa
20 µg/$1,107
SUMO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
7.9 kDa
20 µg/$150
SUMO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
10.7 kDa
20 µg/$150
SUMO2 Protein
Select
E. coli
6His, N-terminus
13.2 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13kD
10 µg/$218; 50 µg/$233; 500 µg/$355; 1 mg/$416
SUMO2 Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.0 kDa
10 µg/$220; 50 µg/$233
Viewing 1-15 of 15 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).