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Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
Gene Name: | sulfotransferase family, cytosolic, 2B, member 1 |
Synonyms: | SULT2B1, Alcohol sulfotransferase, HSST2, ST2B1, Sulfotransferase 2B1 |
Target Sequences: | NM_004605 NP_004596.2 O00204 |
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