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STRADA / LYK5

STE20-related kinase adaptor alpha

STRADA / LYK5 contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.

Gene Name: STE20-related kinase adaptor alpha
Family/Subfamily: Protein kinase , STLK
Synonyms: STRADA, Protein kinase LYK5, LYK5, Stlk, NY-BR-96, PMSE, STE20-like pseudokinase, STE20-related adapter protein, STRAD, STRAD alpha
Target Sequences: NM_001003787 NP_001003787.1 Q7RTN6

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Products
Proteins (14)
Over-Expression Lysate (10)
Recombinant (4)
STRADA / LYK5 (14)
No (14)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (10)
Human (9)
293T Cells (5)
E. coli (2)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (2)
STRADA / LYK5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.2 kDa
20 µg/$215
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.5 kDa
20 µg/$150
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.4 kDa
20 µg/$150
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.1 kDa
20 µg/$150
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.4 kDa
20 µg/$150
STRADA / LYK5 Protein - 12.5% SDS-PAGE of human LYK5 stained with Coomassie Blue
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Wheat Germ Extract
GST
65 kDa
10 µg/$479; 25 µg/$670
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.4 kDa
100 µg/$494
STRADA / LYK5 Protein
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E. coli
His, N-Terminal
38.4 kDa
50 µg/$419
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.1 kDa
100 µg/$494
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.4 kDa
100 µg/$494
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.2 kDa
100 µg/$710
STRADA / LYK5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.5 kDa
100 µg/$494
STRADA / LYK5 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Viewing 1-14 of 14 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).