STK11 / LKB1

serine/threonine kinase 11

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro).

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

STK11 / LKB1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human STK11 / LKB1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21703

Source:

E. coli

Tag:

His-SUMO

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

64.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human STK11 / LKB1 Protein (Recombinant His) - LS-G3169

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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STK11 / LKB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123176

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

100 µg/$494

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Human STK11 / LKB1 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144845

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

74.5 kDa

Price:

50 µg/$419

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Human STK11 / LKB1 Protein (Recombinant GST) (Full Length) - LS-G30580

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.37 kDa

Price:

2 µg/$439

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Mouse STK11 / LKB1 Protein (Recombinant His-T7) (aa49-309) - LS-G25841

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.4 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human STK11 / LKB1 Protein (Recombinant GST, N-terminus) (aa321-433) - LS-G60244

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human STK11 / LKB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78754

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$150

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