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STEAP4

STEAP family member 4

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

Gene Name:	STEAP family member 4
Synonyms:	STEAP4, STEAP family member 4, Metalloreductase STEAP4, STAMP2, TIARP, TNFAIP9
Target Sequences:	NM_024636 NP_078912.2 Q687X5

Publications (1)

Monoclonal antibody to the six-transmembrane epithelial antigen of prostate 4 promotes apoptosis and inhibits proliferation and glucose uptake in human adipocytes. Da-Ni Qin, Chun-Zhao Kou, Yu-Hui Ni, Chun-Mei Zhang, Jin-Gai Zhu, Chun Zhu, Yan-Ping Wang, Guan-Zhong Zhu, Chunmei Shi, Chen-Bo Ji, Xi-Rong Guo. International journal of molecular medicine. 2010 December;26:803-11. [Full Text Article] [PubMed:21042773] Related Antibodies: LS-C75988.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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