STAT5B

signal transducer and activator of transcription 5B

STAT5B is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

STAT5B (8)

Publications

No (8)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human STAT5B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89057

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.7 kDa

Price:

20 µg/$150

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STAT5B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114420

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.7 kDa

Price:

100 µg/$494

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Human STAT5B Protein (Recombinant GST) (Full Length) - LS-G30569

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.42 kDa

Price:

10 µg/$479; 25 µg/$670

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Human STAT5B Protein (Recombinant His-T7) (aa497-749) - LS-G24445

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human STAT5B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71170

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.7 kDa

Price:

20 µg/$1,107

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Human STAT5B Protein (Recombinant GST, N-terminus) (aa678-787) - LS-G60229

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human STAT5B Protein (Recombinant 6His, C-terminus) (Met1-Thr321) - LS-G140397

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.4 kDa

Price:

10 µg/$344; 50 µg/$584

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Human STAT5B Protein (Recombinant 6His, C-terminus) (Met1-Thr321) - LS-G39729

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353

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