STAT5A

signal transducer and activator of transcription 5A

STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

STAT5A (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human STAT5A Protein (Recombinant His, N-Terminal) (aa586-688) - LS-G24448

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

13.2 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human STAT5A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66968

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.5 kDa

Price:

20 µg/$1,107

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Human STAT5A Protein (Recombinant GST, N-terminus) (aa1-104) - LS-G60230

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human STAT5A Protein (Recombinant His) (aa673-773) - LS-G24447

Source:

E. coli

Tag:

His

Molecular Weight:

12.5 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human STAT5A Protein (Recombinant GST) (Full Length) - LS-G30567

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

117 kDa

Price:

10 µg/$479; 25 µg/$670

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Human STAT5A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78827

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.5 kDa

Price:

20 µg/$150

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STAT5A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117521

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.5 kDa

Price:

100 µg/$494

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