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STAT4

signal transducer and activator of transcription 4

STAT4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene Name: signal transducer and activator of transcription 4
Synonyms: STAT4, SLEB11
Target Sequences: NM_003151 NP_003142.1 Q14765

Publications (1)

1
A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö. Nature methods. 2018 May;15:330-338. [Full Text Article] [PubMed:29638227] [PMC:PMC6063793] Related Antibodies: LS-B5539.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
STAT4 (5)
No (5)
GST (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
STAT4 Protein - Recombinant  Signal Transducer And Activator Of Transcription 4 By SDS-PAGE
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E. coli
His, N-Terminal
30.2 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
STAT4 Protein - Purified recombinant protein STAT4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
85.8 kDa
20 µg/$1,107
STAT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
85.8 kDa
20 µg/$150
STAT4 Protein - 12.5% SDS-PAGE of human STAT4 stained with Coomassie Blue
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Wheat Germ Extract
GST
108.02 kDa
10 µg/$479; 25 µg/$670
STAT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
85.8 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).