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STAP2

signal transducing adaptor family member 2

STAP2 is the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.

Gene Name:	signal transducing adaptor family member 2
Synonyms:	STAP2, BRK substrate, BKS, Brk kinase substrate, STAP-2, Breast tumor kinase substrate
Target Sequences:	NM_017720 NP_060190.2 Q9UGK3

Publications (4)

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T. Biochemical and biophysical research communications. 2009 384:71-5. [PubMed:19393627] Related Antibodies: LS-B4920.

Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. Sekine Y, Ikeda O, Tsuji S, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. Journal of immunology (Baltimore, Md. : 1950). 2009 183:7966-74. [PubMed:19933863] Related Antibodies: LS-B4920.

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells. Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. The Journal of biological chemistry. 2010 285:38093-103. [PubMed:20929863] [PMC:PMC2992243] Related Antibodies: LS-B4920.

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. Cancer science. 2011 102:756-61. [PubMed:21205088] Related Antibodies: LS-B4920.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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