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STAM2

signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gene Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: STAM2, Hrs-binding protein, HBP, STAM2B, STAM-2, HSE1 homolog, STAM2A
Target Sequences: NM_005843 NP_005834.4 O75886

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).