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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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ST6GALNAC4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
ST6GALNAC4 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 |
| Synonyms: | ST6GALNAC4, Sialyltransferase 3C, Sialyltransferase 7D, SIAT3-C, SIAT7-D, SIAT3C, ST6GalNAc IV, ST6GALNACIV, SIAT7D |
| Target Sequences: | AF162789 Q9H4F1 Q9H4F1 |
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