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SSTR2

somatostatin receptor 2

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Gene Name: somatostatin receptor 2
Family/Subfamily: GPCR , Somatostatin
Synonyms: SSTR2, Somatostatin receptor 2, SS2R, SST2, Somatostatin receptor II, SRIF-1, Somatostatin receptor type 2, SS-2-R, SS2-R, SSTR2A, Somatostatin receptor 2a
Target Sequences: NM_001050 NP_001041.1 P30874

Publications (8)

1
Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody. Dournaud P, Gu YZ, Schonbrunn A, Mazella J, Tannenbaum GS, Beaudet A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 16:4468-78. (ICC, WB; Rat) [PubMed:8699257]
2
Coupling specificity between somatostatin receptor sst2A and G proteins: isolation of the receptor-G protein complex with a receptor antibody. Gu YZ, Schonbrunn A. Molecular endocrinology (Baltimore, Md.). 1997 11:527-37. (IP; Rat) [PubMed:9139797]
3
Immunohistochemical localization of somatostatin receptors sst2A in human tumors. Reubi JC, Kappeler A, Waser B, Laissue J, Hipkin RW, Schonbrunn A. The American journal of pathology. 1998 153:233-45. (WB, IHC-P, IHC-Fr; Human) [PubMed:9665484] [PMC:PMC1852945]
4
Immunohistochemical detection of somatostatin sst2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts. Reubi JC, Laissue JA, Waser B, Steffen DL, Hipkin RW, Schonbrunn A. The Journal of clinical endocrinology and metabolism. 1999 84:2942-50. (WB, IHC-P, IHC-Fr; Human) [PubMed:10443702]
5
Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Volante M, Brizzi MP, Faggiano A, La Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C, De Rosa G, Dogliotti L, Colao A, Papotti M. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2007 20:1172-82. (IHC-P; Human) [PubMed:17873898]
6
Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins. Li F, Ryu BY, Krueger RL, Heldt SA, Albritton LM. Journal of virology. 2012 86:373-81. [PubMed:22013043] [PMC:PMC3255891]
7
Tumor-associated macrophages in glioblastoma multiforme-a suitable target for somatostatin receptor-based imaging and therapy?. Lapa C, Linsenmann T, Lückerath K, Samnick S, Herrmann K, Stoffer C, Ernestus RI, Buck AK, Löhr M, Monoranu CM. PloS one. 2015 10:e0122269. (ICC; Human) [Full Text Article] [PubMed:25807228] [PMC:PMC4373835] Related Antibodies: LS-C75923.
8
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic ß- and a-cells. Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M. American journal of physiology. Endocrinology and metabolism. 2012 303:E1107-16. (WB; Human) [Full Text Article] [PubMed:22932785]
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Antibodies (33)
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SSTR2 (33)
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SSTR2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SSTR2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
SSTR2 Antibody - Anti-SSTR2 antibody IHC of human brain, subiculum neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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SSTR2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
SSTR2 Antibody - Anti-SSTR2 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
Cancer Pathology
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SSTR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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SSTR2 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IHC-P
Unconjugated
100 µg/$941
SSTR2 Antibody - Western blot analysis using SSTR2 mAb against HEK293 (1) and SSTR2-hIgGFc transfected HEK293 (2) cell lysate.
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SSTR2 Mouse anti-Human Monoclonal (6A1C6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
SSTR2 Antibody - Rat tissue paraffin embedded.
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SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-Fr, IP, WB
Unconjugated
0.1 ml/$386
SSTR2 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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SSTR2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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SSTR2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
SSTR2 Antibody - Western blot of Human Fetal Brain. SSTR2 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SSTR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SSTR2 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$649
SSTR2 Antibody - Immunohistochemistry of paraffin-embedded Human stomach using SSTR2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
SSTR2 Antibody - Immunohistochemistry of paraffin-embedded human stomach tissue.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SSTR2 Antibody - Western blot analysis using SSTR2 mAb against HEK293 (1) and SSTR2 (AA: ***)-hIgGFc transfected HEK293 (2) cell lysate.
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SSTR2 Mouse anti-Human Monoclonal (6H9D2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$459
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SSTR2 Antibody - Western Blot (WB) analysis of SH-SY5Y lysis using SSTR2 antibody.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SSTR2 Antibody - Immunofluorescence analysis of C6 cells using SSTR2 Polyclonal Antibody at dilution of 1:100 (40x lens).Blue: DAPI for nuclear staining.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SSTR2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
100 µl/$755
SSTR2 Antibody - Western blot analysis of SS2R expression in HEK293 cells. The lane on the left is treated with the antigen-specific peptide.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
SSTR2 Antibody - SSTR2 antibody Western blot of Fetal Muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SSTR2 Rabbit anti-Human Polyclonal (aa241-290) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
SSTR2 Antibody - Western blot - Anti-Somatostatin Receptor 2 Antibody
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SSTR2 Rabbit anti-Human Polyclonal (aa184-198) Antibody
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
SSTR2 Antibody - Western blot analysis of extracts of various cell lines, using SSTR2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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SSTR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).