SS18L1 / CREST

synovial sarcoma translocation gene on chromosome 18-like 1

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.

☰ Filters

Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SS18L1 / CREST (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Select

Human SS18L1 / CREST Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94018

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

Select

Human SS18L1 / CREST Protein (Recombinant GST, N-terminus) (aa112-200) - LS-G62132

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

SS18L1 / CREST Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103422

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

Viewing 1-3 of 3 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.