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SRSF2 / SC35
serine/arginine-rich splicing factor 2
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
| Gene Name: | serine/arginine-rich splicing factor 2 |
| Synonyms: | SRSF2, PR264, Protein PR264, SFRS2, Splicing component, 35 kDa, Splicing factor sc35, SR splicing factor 2, SRp30b, SC35, SC-35, SFRS2A |
| Target Sequences: | NM_003016 NP_003007.2 Q01130 |
Publications (1)
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