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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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SRGAP2

SLIT-ROBO Rho GTPase activating protein 2

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Gene Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: SRGAP2, ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, Formin-binding protein 2, SRGAP2A
Target Sequences: O75044 O75044

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IgG (2)
No (5)
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Rabbit Polyclonal (IgG) to Human SRGAP2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $355.00
SRGAP2 Antibody - HEK293 overexpressing Human srGAP2 and probed with at 2.5ug/ml in the right panel. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong University.
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Goat Polyclonal to Human SRGAP2
Rabbit, Mouse, Rat, Hamster, Horse, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
SRGAP2 Antibody - All lanes: Anti-SRGAP2 Antibody (C-term) at 1:2000 dilution. Lane 1: MCF-7 whole cell lysate. Lane 2: SW480 whole cell lysate. Lane 3: SH-SY5Y whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 121 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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Rabbit Polyclonal to Human SRGAP2
Human
Peptide-ELISA, WB
Unconjugated
200µl   $325.00
SRGAP2 Antibody - All lanes: Anti-SRGAP2 Antibody (C-term) at 1:2000 dilution. Lane 1: MCF-7 whole cell lysate. Lane 2: DU145 whole cell lysate. Lane 3: SW480 whole cell lysate. Lane 4: SH-SY5Y whole cell lysate. Lane 5: human cerebellum lysate. Lane 6: mouse brain lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 121 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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Rabbit Polyclonal to Human SRGAP2
Mouse, Human
Peptide-ELISA, WB
Unconjugated
200µl   $325.00
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Rabbit Polyclonal (IgG) to Human SRGAP2
Mouse, Human
WB
AP Conjugated
100µl   $295.00; 200µl   $385.00

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).