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SREBF2 / SREBP2

sterol regulatory element binding transcription factor 2

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

Gene Name: sterol regulatory element binding transcription factor 2
Synonyms: SREBF2, SREBP2, SREBP-2, BHLHd2
Target Sequences: NM_004599 NP_004590.2 Q12772

Publications (3)

1
Effect of cholesterol reduction on receptor signaling in neurons. Fukui K, Ferris HA, Kahn CR. The Journal of biological chemistry. 2015 290:26383-92. (WB; Mouse) [Full Text Article] [PubMed:26370080] [PMC:PMC4646295] Related Antibodies: LS-B1609.
2
Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Proceedings of the National Academy of Sciences of the United States of America. 2017 January;114:1189-1194. (Human) [Full Text Article] [PubMed:28096339] [PMC:PMC5293102] Related Antibodies: LS-B1609.
3
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice. Giulia Birolini , Marta Valenza , Eleonora Di Paolo , Elena Vezzoli, Francesca Talpo, Claudia Maniezzi, Claudio Caccia, Valerio Leoni, Franco Taroni, Vittoria D Bocchi, Paola Conforti, Elisa Sogne, Lara Petricca, Cristina Cariulo, Margherita Verani, Andrea Caricasole, Andrea Falqui, Gerardo Biella, Elena Cattaneo. EMBO molecular medicine. 2020 October;12:e12519. [Full Text Article] [PubMed:32959531] [PMC:PMC7539329]

☰ Filters
Products
Antibodies (33)
Primary (33)
SREBF2 / SREBP2 (33)
Human (32)
Mouse (15)
Rat (13)
Bat (6)
Bovine (7)
Chicken (7)
Chimpanzee (6)
Dog (7)
Gibbon (3)
Guinea pig (6)
Hamster (7)
Horse (7)
Monkey (7)
Pig (7)
Rabbit (3)
Zebrafish (1)
IHC (21)
IHC-P (12)
WB (27)
ELISA (12)
ICC (6)
IF (8)
IP (2)
Peptide-ELISA (1)
rabbit (31)
mouse (2)
Product Group
IHCPlus (4)
IgG (20)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (31)
OTI4G1 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (19)
aa399-427 (7)
aa304-353 (4)
aa434-483 (4)
aa117-380 (2)
aa300-350 (1)
aa441-473 (1)
aa455-469 (1)
No (32)
Yes (1)
SREBF2 / SREBP2 Antibody - Nuclear Staining in Human Testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa455-469) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Mouse, Dog, Human, Monkey
ICC, IHC-P, WB
Unconjugated
1 Each/$485
SREBF2 / SREBP2 Antibody - Anti-SREBP-2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SREBF2 / SREBP2 Antibody - Anti-SREBP-2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (HRP) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Anti-SREBP-2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (Biotin) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Anti-SREBP-2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (FITC) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Western blot analysis of extracts of various cell lines, using SREBF2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SREBF2 / SREBP2 Antibody - Anti-SREBP-2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SREBF2 / SREBP2 Antibody - Liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SREBF2 / SREBP2 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
SREBF2 / SREBP2 Antibody - SREBF2 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SREBF2 / SREBP2 Antibody - Western blot of lysates from Zebrafish and zebra fish muscle tissue lysate (from left to right) with (DANRE) srebf2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
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SREBF2 / SREBP2 Rabbit anti-Zebrafish Polyclonal (aa441-473) Antibody
Zebrafish
WB
Unconjugated
400 µl/$393
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$406
SREBF2 / SREBP2 Antibody - Immunohistochemistry image of paraffin-embedded human kidney tissue at a dilution of 1:100
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SREBF2 / SREBP2 Antibody - 1:100 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SREBF2 / SREBP2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using SREBF2 Polyclonal Antibody at dilution of 1:50(×200)
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SREBF2 / SREBP2 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer tissue  using SREBF2 Polyclonal Antibody at dilution of 1:50(×200)
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 33 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).