SREBF1 / SREBP-1

sterol regulatory element binding transcription factor 1

SREBF1 / SREBP-1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

SREBF1 / SREBP-1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Mouse SREBF1 / SREBP-1 Protein (Recombinant His-T7) (aa158-390) - LS-G25146

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human SREBF1 / SREBP-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78963

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.5 kDa

Price:

20 µg/$150

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SREBF1 / SREBP-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122338

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.5 kDa

Price:

100 µg/$494

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Human SREBF1 / SREBP-1 Protein (Recombinant GST, N-terminus) (aa801-900) - LS-G60202

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SREBF1 / SREBP-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116823

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.2 kDa

Price:

100 µg/$494

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Human SREBF1 / SREBP-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78964

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.2 kDa

Price:

20 µg/$150

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