SR Protein / RNPS1

RNA binding protein S1, serine-rich domain

Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

SR Protein / RNPS1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SR Protein / RNPS1 (Recombinant GST, N-terminus) (aa158-239) - LS-G61678

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SR Protein / RNPS1 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115134

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

100 µg/$494

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SR Protein / RNPS1 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107847

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

100 µg/$494

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Human SR Protein / RNPS1 (Recombinant GST) (Full Length) - LS-G32394

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SR Protein / RNPS1 (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66898

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$1,107

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Human SR Protein / RNPS1 (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66899

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$1,107

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Human SR Protein / RNPS1 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78674

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$150

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Human SR Protein / RNPS1 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78675

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$150

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