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SQSTM1

sequestosome 1

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.

Gene Name: sequestosome 1
Synonyms: SQSTM1, A170, ORCA, OSIL, Paget disease of bone 3, p60, p62, PDB3, Sequestosome-1, Ubiquitin-binding protein p62, Oxidative stress induced like, p62B, ZIP3, Sequestosome 1, EBI3-associated protein p60, EBIAP
Target Sequences: NM_003900 NP_003891.1 Q13501

Publications (5)

1
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. Ju JS, Miller SE, Hanson PI, Weihl CC. The Journal of biological chemistry. 2008 283:30289-99. [PubMed:18715868] [PMC:PMC2573070] Related Antibodies: LS-C161484.
2
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C161484.
3
Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. Hubbs AF, Fluharty KL, Edwards RJ, Barnabei JL, Grantham JT, Palmer SM, Kelly F, Sargent LM, Reynolds SH, Mercer RR, Goravanahally MP, Kashon ML, Honaker JC, Jackson MC, Cumpston AM, Goldsmith WT, McKinney W, Fedan JS, Battelli LA, Munro T, Bucklew-Moyers W, McKinstry K, Schwegler-Berry D, Friend S, Knepp AK, Smith SL, Sriram K. The American journal of pathology. 2016 186:2887-2908. (IF; Mouse) [Full Text Article] [PubMed:27643531] [PMC:PMC5222965] Related Antibodies: LS-B4617.
4
Improved efficacy of a next-generation ERT in murine Pompe disease. Xu S, Lun Y, Frascella M, Garcia A, Soska R, Nair A, Ponery AS, Schilling A, Feng J, Tuske S, Valle MCD, Martina JA, Ralston E, Gotschall R, Valenzano KJ, Puertollano R, Do HV, Raben N, Khanna R. JCI insight. 2019 March;4:pii: 125358. [Full Text Article] [PubMed:30843882] [PMC:PMC6483515] Related Antibodies: LS-B4617.
5
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury. Xin Zhang, Yingli Jing, Chuan Qin, Changbin Liu, Degang Yang, Feng Gao, Mingliang Yang, Liangjie Du, Jianjun Li. Journal of cellular and molecular medicine. 2020 November;24:12765-12776. [Full Text Article] [PubMed:32945105] [PMC:PMC7686991] Related Antibodies: LS-C313090.
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Antibodies (137)
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SQSTM1 (151)
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SQSTM1 Antibody - Anti-SQSTM1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SQSTM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
SQSTM1 Antibody - P62 / SQSTM1 antibody. IHC(P): Human Intestinal Cancer Tissue.
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SQSTM1 Rabbit anti-Human Polyclonal (aa91-110) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SQSTM1 Antibody - Anti-SQSTM1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SQSTM1 Rabbit anti-Human Polyclonal (aa323-372) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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SQSTM1 Guinea pig anti-Human Polyclonal (aa421-440) Antibody
Rabbit, Mouse, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$993
SQSTM1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SQSTM1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
SQSTM1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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SQSTM1 Rabbit anti-Human Polyclonal (aa317-346) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SQSTM1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody.
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SQSTM1 Mouse anti-Human Monoclonal (OTI4E2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody.
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SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4E2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SQSTM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC-P, WB
Unconjugated
0.1 ml/$460
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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SQSTM1 Mouse anti-Human Monoclonal (OTI1E9) Antibody
Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1E9) Antibody
Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-SQSTM1 mouse monoclonal antibody.
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SQSTM1 Mouse anti-Human Monoclonal (OTI5A1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Antibody - Dot blot of SQSTM1 Antibody (Phospho S207) Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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SQSTM1 Rabbit anti-Human Polyclonal (pSer207) Antibody
Human
DB
Unconjugated
400 µl/$393
SQSTM1 Antibody - Immunohistochemistry of p62 immunoreactivity is present in neurons of the hippocampus of an Alzheimer patient. Note the intense reaction in the neurofibrillary tangles (dilution 1:1000). Micrograph courtesy of Professor Fred van Leeuwen, University of Maastricht, The Netherlands.
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SQSTM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$553
SQSTM1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SQSTM1 Rabbit anti-Human Polyclonal (aa325-375) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
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SQSTM1 Rabbit anti-Human Polyclonal (aa317-346) (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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SQSTM1 Rabbit anti-Human Polyclonal (aa300-360) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$393
SQSTM1 Antibody - Detection of Human Sequestosome-1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-Sequestosome-1 used at a dilution of 1:200 (1 ug/ml). Detection: Vector Laboratories ImmPACT NovaRED Peroxidase Substrate.
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SQSTM1 Rabbit anti-Human Polyclonal (aa425-440) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SQSTM1 Antibody - Detection limit for recombinant GST tagged SQSTM1 is approximately 3 ng/ml as a capture antibody.
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SQSTM1 Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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SQSTM1 Mouse anti-Human Monoclonal (OTI4A12) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SQSTM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4A12) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Antibody - IHC of paraffin-embedded Human liver tissue using anti-SQSTM1 mouse monoclonal antibody.
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SQSTM1 Mouse anti-Human Monoclonal (OTI5A2) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Antibody - IHC of paraffin-embedded Human liver tissue using anti-SQSTM1 mouse monoclonal antibody.
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SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5A2) Antibody
Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-25 of 151 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).