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Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.
Gene Name: | serine palmitoyltransferase, small subunit A |
Synonyms: | SPTSSA, C14orf147, SSSPTA |
Target Sequences: | H07000 |
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