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SPTLC2 / LCB2

serine palmitoyltransferase, long chain base subunit 2

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.

Gene Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: SPTLC2, HSN1C, HLCB2a, KIAA0526, LCB2, LCB2A, SPT 2, NSAN1C, SPT2, LCB 2, Serine palmitoyltransferase 2
Target Sequences: NM_004863 NP_004854.1 O15270

Publications (1)

1
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ. Nature communications. 2015 6:10166. (ICC; Human) [Full Text Article] [PubMed:26670557] [PMC:PMC4682112] Related Antibodies: LS-B9514.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
SPTLC2 / LCB2 (6)
No (6)
GST (1)
GST, N-terminus (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
SPTLC2 / LCB2 Protein
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E. coli
His-SUMO
69.69 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
SPTLC2 / LCB2 Protein - 12.5% SDS-PAGE of human SPTLC2 stained with Coomassie Blue
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Wheat Germ Extract
GST
89.3 kDa
2 µg/$439
SPTLC2 / LCB2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SPTLC2 / LCB2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.7 kDa
20 µg/$150
SPTLC2 / LCB2 Protein - Recombinant  Serine Palmitoyltransferase, Long Chain Base Subunit 2 By SDS-PAGE
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E. coli
His-T7
15.9 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
SPTLC2 / LCB2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).