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SPTAN1 / Alpha Fodrin

spectrin, alpha, non-erythrocytic 1

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Gene Name: spectrin, alpha, non-erythrocytic 1
Synonyms: SPTAN1, Alpha-II spectrin, Alpha Fodrin, Fodrin alpha chain, EIEE5, NEAS, Alpha-fodrin, Spectrin alpha chain, brain, SPTA2
Target Sequences: NM_003127 NP_003118.2 Q13813

Publications (2)

1
Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice. Christensen IB, Gyldenholm T, Damkier HH, Praetorius J. Frontiers in physiology. 2013 4:344. (IHC; Mouse) [Full Text Article] [PubMed:24348423] [PMC:PMC3842056]
2
Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium. Christensen IB, Wu Q, Bohlbro AS, Skals MG, Damkier HH, Hübner CA, Fenton RA, Praetorius J. Fluids and barriers of the CNS. 2020 January;17:2. [Full Text Article] [PubMed:31906971] [PMC:PMC6945596]

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Proteins (17)
Recombinant (17)
SPTAN1 / Alpha Fodrin (17)
No (17)
6His-SUMO, N-terminus (1)
His (13)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Chicken (4)
Human (6)
Mouse (4)
Rat (3)
E. coli (15)
HEK 293 Cells (2)
Purified (1)
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His, N-Terminal
20.4 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
SPTAN1 / Alpha Fodrin Protein - Purified recombinant protein SPTAN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
284.9 kDa
20 µg/$1,107
SPTAN1 / Alpha Fodrin Protein - Purified recombinant protein SPTAN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
284.4 kDa
20 µg/$1,107
SPTAN1 / Alpha Fodrin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
25.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
24.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
15.1 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
19.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
Select
E. coli
His
25.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
24.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
23.9 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
26.0 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
15.2 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
22.8 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
Select
E. coli
His
22.9 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
Select
E. coli
His
22.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
SPTAN1 / Alpha Fodrin Protein - Recombinant Alpha-Fodrin By SDS-PAGE
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E. coli
His
17.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).