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SPPL2B
signal peptide peptidase like 2B
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
| Gene Name: | signal peptide peptidase like 2B |
| Family/Subfamily: | Protease , Aspartic A22B |
| Synonyms: | SPPL2B, Intramembrane protease 4, Presenilin-like protein 1, KIAA1532, PSH4, PSL1, SPP-like 2B, IMP-4, SNPPL2B |
| Target Sequences: | AB040965 BAA96056.1 Q8TCT7 |
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