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SPP1 / Osteopontin

secreted phosphoprotein 1

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Name:	secreted phosphoprotein 1
Synonyms:	SPP1, BSPI, BNSP, Bone sialoprotein 1, ETA-1, Nephropontin, OPN, Secreted phosphoprotein 1, SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, Uropontin, Osteopontin, Bone sialoprotein I
Target Sequences:	NM_000582 NP_000573.1 P10451

Publications (8)

Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, Rashid MM, Morimoto J, Inobe M, Shijubo N, Chambers AF, Uede T. Journal of cellular biochemistry. 2002 84:420-32. [PubMed:11787071]

Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Robertson BW, Chellaiah MA. Experimental cell research. 2010 316:11-Jan. [PubMed:19850036] [PMC:PMC2787770] Related Antibodies: LS-B425.

Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Rui YF, Lui PP, Rolf CG, Wong YM, Lee YW, Chan KM. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2012 20:1409-17. (IHC; Human) [PubMed:21946950]

Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR-induced -catenin degradation. Xu L, Song C, Ni M, Meng F, Xie H, Li G. The international journal of biochemistry & cell biology. 2012 44:612-9. [PubMed:22230368]

Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B425.

Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease. Denise Traxler, Andreas Spannbauer, Patrick Einzinger, Julia Mester-Tonczar, Dominika Lukovic, Johannes Winkler, Katrin Zlabinger, Alfred Gugerell, LJubica Mandic, Mariann Gyöngyösi, Noemi Pavo. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32605184] [PMC:PMC7369988]

Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression. Chia-Hung Hsu, Hon-Ping Ma, Jiann Ruey Ong, Ming-Shou Hsieh, Vijesh Kumar Yadav, Chi-Tai Yeh, Tsu-Yi Chao, Wei-Hwa Lee, Wen-Chien Huang, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chih-Ming Su. Disease Markers. 2022 July;2022:8446629. [Full Text Article] [PubMed:35903297] [PMC:PMC9325341]

Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization. Anja Schlecht, Peipei Zhang, Julian Wolf, Adrian Thien, Dennis-Dominik Rosmus, Stefaniya Boneva, Günther Schlunck, Clemens Lange, Peter Wieghofer. Frontiers in cell and developmental biology. 2021 February;8:618598. [Full Text Article] [PubMed:33585455] [PMC:PMC7876283] Related Antibodies: LS-C169155.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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