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SPOPL
speckle-type POZ protein-like
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
| Gene Name: | speckle-type POZ protein-like |
| Synonyms: | SPOPL, Roadkill homolog 2, Speckle-type POZ protein-like, BTBD33, HIB homolog 2 |
| Target Sequences: | Q6IQ16 Q6IQ16 |
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