SPINT2 / HAI-2 is a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
|Gene Name:||serine peptidase inhibitor, Kunitz type, 2|
|Family/Subfamily:||Serine Protease Inhibitor , not assigned-Serine Protease Inhibitor|
|Synonyms:||SPINT2, DIAR3, HAI-2, HAI2, Placental bikunin, Kop|
|Target Sequences:||NM_021102 NP_066925.1 O43291|
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