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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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SPINLW1 / EPPIN
epididymal peptidase inhibitor
SPINLW1 / EPPIN is an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | epididymal peptidase inhibitor |
| Synonyms: | EPPIN, Cancer/testis antigen 71, CT71, DJ461P17.2, EPPIN1, EPPIN2, EPPIN3, Epididymal protease inhibitor, WAP7, Protease inhibitor WAP7, Cancer/testis antigen 72, CT72, Epididymal peptidase inhibitor, SPINLW1, WFDC7 |
| Target Sequences: | NM_020398 NP_065131.1 O95925 |
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