SPHK2

sphingosine kinase 2

Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)- only proteins, a pro-apoptotic subgroup of the Bcl-2 family. Co-immunoprecipitation demonstrated that SphK2 interacted with Bcl-xL; however, mutation of the conserved leucine residue present in all BH3 domains only partially reduced apoptosis induced by SphK2, suggesting that the SphK2 protein possesses additional determinants important for this function.

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Products

Proteins (4)

Type

Recombinant (4)

Target

SPHK2 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (4)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SPHK2 Protein (Recombinant GST) (Full Length) - LS-G34578

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

95.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SPHK2 Protein (Recombinant His-T7, N-terminus) (Met1-Asn188) - LS-G133406

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

24.3kDa

Price:

10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human SPHK2 Protein (Recombinant GST, N-terminus) (aa531-635) - LS-G62865

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SPHK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72015

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

20 µg/$1,107

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