SPHK2

sphingosine kinase 2

Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)- only proteins, a pro-apoptotic subgroup of the Bcl-2 family. Co-immunoprecipitation demonstrated that SphK2 interacted with Bcl-xL; however, mutation of the conserved leucine residue present in all BH3 domains only partially reduced apoptosis induced by SphK2, suggesting that the SphK2 protein possesses additional determinants important for this function.

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ELISA Kits (3)

Type

Cell-Based (1)

Custom (1)

Sandwich (1)

Target

SPHK2 (3)

Reactivity

Human (2)

Mouse (2)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

Publications

No (3)

Sample Type

Adherent Cell Cultures (1)

Plasma (1)

Serum (1)

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Mouse SPHK2 (Sandwich ELISA) ELISA Kit - LS-F14314

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human SPHK2 (Custom ELISA) ELISA Kit - LS-F14315

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse/Human/Rat SPHK2 (Cell-Based ELISA) ELISA Kit - LS-F2321

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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