SPHK2

sphingosine kinase 2

Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)- only proteins, a pro-apoptotic subgroup of the Bcl-2 family. Co-immunoprecipitation demonstrated that SphK2 interacted with Bcl-xL; however, mutation of the conserved leucine residue present in all BH3 domains only partially reduced apoptosis induced by SphK2, suggesting that the SphK2 protein possesses additional determinants important for this function.

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Products

Antibodies (39)

Proteins (4)

ELISA Kits (3)

Type

Cell-Based (1)

Custom (1)

Primary (39)

Recombinant (4)

Sandwich (1)

Target

SPHK2 (46)

Reactivity

Human (41)

Mouse (13)

Rat (9)

Application

IHC (29)

IHC-P (6)

WB (32)

Flo (5)

ELISA (23)

ICC (1)

IF (2)

IP (1)

Peptide-ELISA (4)

Host

rabbit (37)

mouse (2)

Product Group

IHCPlus (1)

Isotype

IgG (25)

IgG1 (2)

Clonality

monoclonal mc (2)

polyclonal pc (37)

Clone

3C8D3 (1)

9C5E1 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (3)

DY488 Conjugated (1)

DY550 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (24)

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Epitope

N-Terminus (11)

aa590-620 (7)

C-Terminus (3)

550-630 aa (2)

pThr614 (2)

Ab-614 (1)

aa52-84 (1)

aa580-629 (1)

Publications

No (46)

Sample Type

Adherent Cell Cultures (1)

Plasma (1)

Serum (1)

Tag

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (4)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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IHC-plus™ SPHK2 Antibody (N-Terminus) LS-B1101

(4.0) Rating

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

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Mouse SPHK2 (Sandwich ELISA) ELISA Kit - LS-F14314

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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SPHK2 Antibody (aa580-629) LS-C118372

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa580-629) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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SPHK2 Antibody (aa590-620) LS-C100772

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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SPHK2 Antibody (C-Terminus) LS-C368753

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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Human SPHK2 Protein (Recombinant GST) (Full Length) - LS-G34578

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

95.6 kDa

Price:

10 µg/$479; 25 µg/$670

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SPHK2 Antibody LS-C801838

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SPHK2 Antibody (phospho-Thr614) LS-C199598

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (pThr614) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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SPHK2 Antibody (clone 9C5E1) LS-C669354

Antibody:

SPHK2 Mouse anti-Human Monoclonal (9C5E1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC

Format:

Unconjugated

Price:

100 µl/$459

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SPHK2 Antibody (clone 3C8D3) LS-C669356

Antibody:

SPHK2 Mouse anti-Human Monoclonal (3C8D3) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC

Format:

Unconjugated

Price:

100 µl/$459

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SPHK2 Antibody (C-Terminus) LS-C26797

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$466

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SPHK2 Antibody LS-C662532

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SPHK2 Antibody LS-C754208

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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SPHK2 Antibody (aa590-620) LS-C328732

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SPHK2 Antibody (aa590-620, Biotin) LS-C245957

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SPHK2 Antibody (aa590-620, FITC) LS-C245959

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SPHK2 Antibody (aa590-620, APC) LS-C245958

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • APC

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SPHK2 Antibody (N-Terminus) LS-C330672

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SPHK2 Antibody (N-Terminus, Biotin) LS-C245953

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SPHK2 Antibody (N-Terminus, FITC) LS-C245954

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SPHK2 Antibody (N-Terminus, APC) LS-C245952

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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SPHK2 Antibody (N-Terminus, PE) LS-C245955

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE

Select

SPHK2 Antibody (Ab-614) LS-C827668

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (Ab-614) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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SPHK2 Antibody LS-C401405

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SPHK2 Antibody (550-630 aa) LS-C386155

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (550-630 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Viewing 1-25 of 46 product results

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