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SPHK / SPHK1

sphingosine kinase 1

SPHK / SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: sphingosine kinase 1
Family/Subfamily: Non-protein Kinase , Sphingosine
Synonyms: SPHK1, SK1, Sphingosine kinase 1, SPHK, SK 1, SPK 1, Sphingosine kinase type 1, SPK
Target Sequences: NM_021972 NP_068807.2 Q9NYA1

Publications (2)

1
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. Fischer I, Alliod C, Martinier N, Newcombe J, Brana C, Pouly S. PloS one. 2011 6:e23905. [PubMed:21887342] [PMC:PMC3161076] Related Antibodies: LS-C100769.
2
Bone morphogenetic protein-2 enhances gonadotropin-independent follicular development via sphingosine kinase 1. Masami Ito, Osamu Yoshino, Yosuke Ono, Akemi Yamaki-Ushijima, Tomoko Tanaka, Tomoko Shima, Makoto Orisaka, Akira Iwase, Akitoshi Nakashima, Shigeru Saito. American journal of reproductive immunology (New York, N.Y. : 1989). 2021 May;85:e13374. [Full Text Article] [PubMed:33175430] Related Antibodies: LS-A3106.

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SPHK / SPHK1 (8)
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SPHK / SPHK1 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$923
SPHK / SPHK1 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
SPHK / SPHK1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
SPHK / SPHK1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
SPHK / SPHK1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SPHK / SPHK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
SPHK / SPHK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$1,150
SPHK / SPHK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).