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SPDL1 / CCDC99

spindle apparatus coiled-coil protein 1

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.

Gene Name:	spindle apparatus coiled-coil protein 1
Synonyms:	SPDL1, CCDC99
Target Sequences:	NM_017785 NP_060255.3 Q96EA4

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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